The lose a running back but get one back for "Thursday Night Football" in Week 6, while the thought they could have their starting tight end back in the fold until he mi sed practice on Wednesday and was ruled out.We'll break down the injuries you need to know about for that matchup below before digging in to each team playing on Sunday's initial injury report for Week 6. Check back with us throughout the day as we react to all the injury news around the NFL.Eagles (-3) at GiantsEagles:RB (hamstring), DT (calf), LB Nathan Gerry (ankle, knee), LB D.J. Alexander (quad), S (hamstring) OUTGiants:WR (neck), TE (knee) OUT; TE (foot) QUESTIONABLEThe Eagles are hurting at two key positions: running back and safety. was placed on injured Anibal Sanchez Jersey reserve this week with a torn ACL, and Sproles remains sidelined with a hamstring i sue. The good news is that (quad) is good to go after practicing in full this week. He'll pair with to handle the bulk of the team's snaps at running back. At safety, is also on injured reserve, and with Graham out, that means fourth-round rookie is set to play a large role again this week after being on the field for every defensive snap last week in a lo s to the .The Giants will have to make do another week without Engram, who returned to limited practice early in the week but mi sed Wednesday's se sion before being ruled out. Compounding the i sue at the position is that Ellison, who has been filling in, is no lock to play either after limited practices on Tuesday and Wednesday. , who has Joe Blanton Jersey two catches since entering the league in 2014, would be the next man up. One player the Giants will have is pa s rusher , who is set to make his season debut after mi sing the first five games of the season with an ankle injury. Wednesday's injury reports at Vikings (-10.5)Cardinals receiver Larry Fitzgerald (hamstring, back) was one of seven DNPs for the team on Wednesday, though he figures to play at le s than 100 percent as usual on Sunday. Breakout safety Tre Boston (shoulder) and defensive tackle Robert Nkemdiche (foot) also mi sed practice, while linebacker Josh Bynes (wrist) and safety Budda Baker (shoulder) were among six limited players. Vikings left tackle Riley Reiff (foot) and safety Andrew Sendejo (groin) both mi sed practice on Wednesday, while running back Dalvin Cook (hamstring) was limited after being inactive in Week 5. Corner Trae Waynes (concu sion) practiced in full after being held out last week. (-1) at Chargers pa s rusher Joey Bosa remains sidelined with a foot i sue, and linebacker Jatavis Brown (groin) joined him as a DNP on Wednesday. Three of the team's starting offensive linemen were all limited by injury to start the week, as was kicker Caleb Sturgis (quad). Browns receiver was unable to practice after suffering a knee injury on Wednesday. That could mean more targets for rookie or , who emerged late in the team's OT win over the Ravens. Defensive backs (heel) and E.J. Gaines (groin) were among four Browns limited. (-3) at The Bears come out of the bye mostly healthy, with defensive back Marcus Cooper (hamstring) the only player to mi s practice. Corner Prince Amukamara (hamstring) was limited on Wednesday, while rookie receiver Anthony Miller (shoulder) practiced in full. Defensive end (ankle), corner (knee) and safety T.J. McDonald (foot) were the three Dolphins who didn't practice Wednesday due to injury. Six were limited, including left tackle (concu sion) and receivers (quad) and (shoulder). The Grant injury would also be a big blow for the return game if he can't go Sunday. at (- Eric Thames Jersey 1) was a limited participant in practice on Wednesday as he looks to return from a multi-week foot injury. The Panthers tight end had just two catches for 33 yards before fracturing his foot in Week 1. Center (neck) practiced in full. Defensive tackle Kawann Short mi sed practice with an ankle injury. The Panthers are also set to get back from suspension this week. Two key Redskins receivers were listed as not practicing on Wednesday in Jamison Crowder (ankle) and Paul Richardson (shoulder, knee). Eight were limited, including another receiver in Josh Doctson (heel) and the team's top two running backs: Adrian Peterson (ankle, shoulder, knee) and Chris Thompson (rib, knee). This could be a rough week for the Washington offense if multiple skill position guys are out. at (-2.5)Eleven Colts players mi sed practice on Wednesday, but not tackle (hamstring) and running back (hamstring), who both practiced in full. Among the DNPs were receiver T.Y. Hilton (chest, hamstring), tight ends (hip) and (shin, quad, ankle, knee) and rookie linebacker (ankle). Running back (ankle) was one of seven Jets players to mi s practice on Wednesday after rushing for 219 yards on 15 carries in Week 5. Other absences include cornerbacks (quad) and (concu sion). Wide receiver (groin) was one of three limited Jets. at (-2.5)Steelers safety (groin) remained sidelined on Wednesday after mi sing Daniel Murphy Jersey the last three games. Linebacker practiced in full and looks likely to return after mi sing Week 5 with a hamstring injury. Bengals guard (hip) joined rookie center (foot) as non-participants in Wednesday's practice, which could shake up the Bengals' offensive line. Running back (knee) also remained sidelined. Receiver (groin) was limited to start the week, as were four defenders, including defensive ends (knee) and (ankle). at (-3.5)Five Bucs were limited on Wednesday, including tight end O.J. Howard, who sprained his MCL in Week 4 heading into the team's bye. Right tackle Demar Dotson (knee) was also among the limited players. Falcons running back returned to game action this week but sustained a new foot injury during the game, which caused him to mi s practice on Wednesday. Defensive tackle (ankle) also remained sidelined, while receiver (hip) was one of three players limited. (-3) vs. in LondonThe Seahawks are still without linebacker K.J. Wright (knee) and defensive end Rasheem Green (ankle) at practice, but aside from them, the only player who didn't practice in full on Wednesday was tight end Nick Vannett (back). Four players were listed as full participants, including quarterback Ru sell Wilson, who's dealing with a hamstring i sue. The Raiders were mi sing guard Kelechi Osemele (knee) from practice Wednesday in a week that could be problematic for players dealing with injury to play. Considering the long flight involved in getting to London, these teams may be cautious and keep their banged-up players at home. Most of the rest of the offensive line was limited to start the week, as they have been in recent weeks. at (-9.5)The only players to mi s Bills practice were listed as resting, leaving the team with only three injuries to worry about, all in the Kevin Long Jersey secondary. Cornerback (ankle) and safet